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1

Fourier spectral methods for fractional-in-space reaction-diffusion equations

Bueno-Orovio, Alfonso, Kay, David, Burrage, Kevin

Journal:

BIT Numerical Mathematics

Year:

2014

Language:

english

File:

PDF, 2.60 MB

english, 2014

2

Sensitivity analysis of a strongly-coupled human-based electromechanical cardiac model: Effect of mechanical parameters on physiologically relevant biomarkers

Levrero-Florencio, F., Margara, F., Zacur, E., Bueno-Orovio, A., Wang, Z.J., Santiago, A., Aguado-Sierra, J., Houzeaux, G., Grau, V., Kay, D., Vázquez, M., Ruiz-Baier, R., Rodriguez, B.

Journal:

Computer Methods in Applied Mechanics and Engineering

Year:

2020

Language:

english

File:

PDF, 2.52 MB

english, 2020

3

Minimal model for human ventricular action potentials in tissue

Alfonso Bueno-Orovio, Elizabeth M. Cherry, Flavio H. Fenton

Journal:

Journal of Theoretical Biology

Year:

2008

Language:

english

File:

PDF, 2.33 MB

english, 2008

4

Continuous Adjoint Approach for the Spalart-Allmaras Model in Aerodynamic Optimization

Bueno-Orovio, Alfonso, Castro, Carlos, Palacios, Francisco, Zuazua, Enrique

Journal:

Year:

2012

Language:

english

File:

PDF, 3.33 MB

english, 2012

5

Encyclopedia of Cell Biology || Cardiac Modeling

Bueno-Orovio, A.

Year:

2016

Language:

english

File:

PDF, 966 KB

english, 2016

6

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

Muszkiewicz, Anna, Britton, Oliver J., Gemmell, Philip, Passini, Elisa, Sánchez, Carlos, Zhou, Xin, Carusi, Annamaria, Quinn, T. Alexander, Burrage, Kevin, Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Progress in Biophysics and Molecular Biology

Year:

2016

Language:

english

File:

PDF, 1.67 MB

english, 2016

7

Successful integrative approach of the pro-arrhythmic risk assessment of the multichannel ion channel inhibitor vanoxerine, via combination of in silico human cardiomyocyte models and in vivo guinea-pig electromechanical window assay

Morissette, Pierre, Gerenser, Pamela, Travis, Jeffrey, Fanelli, Patrick, Balasubramanian, Bharathi, Passini, Elisa, Bueno-Orovio, Alfonso, Rodriguez, Blanca, Regan, Christopher, Sannajust, Frederick

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2018

Language:

english

File:

PDF, 75 KB

english, 2018

8

Enhanced box and prism assisted algorithms for computing the correlation dimension

Alfonso Bueno-Orovio, Víctor M. Pérez-García

Journal:

Chaos, Solitons & Fractals

Year:

2007

Language:

english

File:

PDF, 486 KB

english, 2007

9

In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular CardiomyocytesNovelty and Significance

Zhou, Xin, Bueno-Orovio, Alfonso, Orini, Michele, Hanson, Ben, Hayward, Martin, Taggart, Peter, Lambiase, Pier D., Burrage, Kevin, Rodriguez, Blanca

Journal:

Circulation Research

Year:

2016

Language:

english

File:

PDF, 5.93 MB

english, 2016

10

In silico prediction of drug effects on human ventricular electrophysiology using the Virtual Assay software and comparison to in vitro data

Passini, Elisa, Britton, Oliver, Lu, Hua Rong, Gallacher, David J., Rohrbacher, Jutta, An, Hermans, Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2016

Language:

english

File:

PDF, 68 KB

english, 2016

11

Reply to the Editor—On misuse of null hypothesis testing: Analysis of biophysical model simulations

Liberos, Alejandro, Bueno-Orovio, Alfonso, Rodrigo, Miguel, Ravens, Ursula, Hernandez-Romero, Ismael, Fernandez-Aviles, Francisco, Guillem, Maria S., Rodriguez, Blanca, Climent, Andreu M.

Journal:

Year:

2017

Language:

english

File:

PDF, 73 KB

english, 2017

12

[ - ()] - The Role of the Ina-Ik1 Complex on Human Ventricular Conduction Velocity

Marinov, Peter, Bueno-Orovio, Alfonso, Rodriguez, Blanca

File:

PDF, 465 KB

13

[American Institute of Aeronautics and Astronautics 49th AIAA Aerospace Sciences Meeting including the New Horizons Forum and Aerospace Exposition - Orlando, Florida ()] 49th AIAA Aerospace Sciences Meeting including the New Horizons Forum and Aerospace Exposition - When the 'Exact' Discrete Gradient is not the Best Choice in Optimal Shape Design

Bueno-Orovio, Alfonso, Castro, Carlos, Duraisamy, Karthikeyan, Palacios, Francisco, Zuazua, Enrique

Year:

2011

Language:

english

File:

PDF, 529 KB

english, 2011

14

Balance between sodium and calcium currents underlying chronic atrial fibrillation termination: An in silico intersubject variability study

Liberos, Alejandro, Bueno-Orovio, Alfonso, Rodrigo, Miguel, Ravens, Ursula, Hernandez-Romero, Ismael, Fernandez-Aviles, Francisco, Guillem, Maria S., Rodriguez, Blanca, Climent, Andreu M.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.17 MB

english, 2016

15

In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment

Margara, Francesca, Wang, Zhinuo J., Levrero-Florencio, Francesc, Santiago, Alfonso, VÃ¡zquez, Mariano, Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Progress in Biophysics and Molecular Biology

Year:

2020

File:

PDF, 32.32 MB

2020

16

[American Institute of Aeronautics and Astronautics 49th AIAA Aerospace Sciences Meeting including the New Horizons Forum and Aerospace Exposition - Orlando, Florida ()] 49th AIAA Aerospace Sciences Meeting including the New Horizons Forum and Aerospace Exposition - Continuous Adjoint Approach for the Spalart-Allmaras Model in Aerodynamic Optimization

Bueno-Orovio, Alfonso, Castro, Carlos, Palacios, Francisco, Zuazua, Enrique

Year:

2011

Language:

english

File:

PDF, 408 KB

english, 2011

17

Fourier embedded domain methods: Periodic and C∞ extension of a function defined on an irregular region to a rectangle via convolution with Gaussian kernels

Alfonso Bueno-Orovio

Journal:

Applied Mathematics and Computation

Year:

2006

Language:

english

File:

PDF, 2.45 MB

english, 2006

18

On the Order of the Fractional Laplacian in Determining the Spatio-Temporal Evolution of a Space-Fractional Model of Cardiac Electrophysiology

Cusimano, Nicole, Bueno-Orovio, Alfonso, Turner, Ian, Burrage, Kevin, Talkachova, Alena

Journal:

Year:

2015

Language:

english

File:

PDF, 1.41 MB

english, 2015

19

In silico evaluation of arrhythmia

Zhou, Xin, Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Current Opinion in Physiology

Year:

2018

Language:

english

File:

PDF, 2.12 MB

english, 2018

20

In Silico Drug Trials with Virtual Assay Software Predict Drug Cardiotoxicity and Identify Sub-Populations at Higher Risk

Passini, Elisa, Britton, Oliver, Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 70 KB

english, 2017

21

Virtual assay: A user-friendly framework for in silico drug trials in populations of human cardiomyocyte models

Passini, Elisa, Britton, Oliver J., Greig, Robert J.H., Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2018

Language:

english

File:

PDF, 55 KB

english, 2018

22

57-03: How Can a Gain-of-Function Mutation in KCNQ1 Lead to Action Potential Prolongation?

Zhou, Xin, Harmer, Stephen, Bueno-Orovio, Alfonso, Burrage, Kevin, Tinker, Andrew, Rodriguez, Blanca

Journal:

Year:

2016

File:

PDF, 115 KB

2016

23

ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk

Mincholé, A., Bueno-Orovio, A., Laguna, P., Pueyo, E., Rodriguez, B.

Journal:

Journal of Electrocardiology

Year:

2015

Language:

english

File:

PDF, 493 KB

english, 2015

24

P503Inter-subject variability explains juxtaposed effects in pharmacological treatments: an in-silico approach for the personalization of atrial fibrillation drug treatments

Liberos, A, Hernandez-Romero, I, De La Nava, A S, Rodrigo, M, Bueno-Orovio, A, Rodriguez, B, Guillem, M S, Atienza, F, Climent, A M, Fernandez-Aviles, F

Journal:

Cardiovascular Research

Year:

2018

Language:

english

File:

PDF, 148 KB

english, 2018

25

In silico electro-mechanical window shortening and repolarisation abnormalities predict clinical risk of torsade de pointes for 40 reference compounds

Passini, Elisa, Bueno-Orovio, Alfonso, Morissette, Pierre, Sannajust, Frederick, Rodriguez, Blanca

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2018

Language:

english

File:

PDF, 48 KB

english, 2018

26

The virtual assay software for human in silico drug trials to augment drug cardiac testing

Passini, Elisa, Zhou, Xin, Trovato, Cristian, Britton, Oliver J, Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Journal of Computational Science

Year:

2020

File:

PDF, 3.02 MB

2020

27

Human in silico trials on drug-induced changes in electrophysiology and calcium dynamics using the virtual assay software

Passini, Elisa, Britton, Oliver J., Bueno-Orovio, Alfonso, Rodriguez, Blanca

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2019

File:

PDF, 184 KB

2019

28

Impact of in vitro ion channel protocols when assessing cardiac pro-arrhythmic risk with in silico models

Morissette, Pierre, Imredy, John, Zhai, Jin, Travis, Jeffrey, Fanelli, Patrick, Dech, Spencer, Regan, Christopher, Bueno-Orovio, Alfonso, Passini, Elisa, Rodriguez, Blanca, Sannajust, Frederick

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2019

File:

PDF, 199 KB

2019

29

Spectral smoothed boundary methods: The role of external boundary conditions

Alfonso Bueno-Orovio, Víctor M. Pérez-García

Journal:

Numerical Methods for Partial Differential Equations

Year:

2006

Language:

english

File:

PDF, 853 KB

english, 2006

30

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop

Rodriguez, Blanca, Carusi, Annamaria, Abi-Gerges, Najah, Ariga, Rina, Britton, Oliver, Bub, Gil, Bueno-Orovio, Alfonso, Burton, Rebecca A. B., Carapella, Valentina, Cardone-Noott, Louie, Daniels, Matt

Journal:

Year:

2015

Language:

english

File:

PDF, 1.03 MB

english, 2015

31

Exact solutions to the fractional time-space Bloch–Torrey equation for magnetic resonance imaging

Bueno-Orovio, Alfonso, Burrage, Kevin

Journal:

Communications in Nonlinear Science and Numerical Simulation

Year:

2017

Language:

english

File:

PDF, 2.52 MB

english, 2017

32

Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment

Zhou, Xin, Qu, Yusheng, Passini, Elisa, Bueno-Orovio, Alfonso, Liu, Yang, Vargas, Hugo M., Rodriguez, Blanca

Journal:

Frontiers in Pharmacology

Year:

2020

Language:

english

File:

PDF, 5.31 MB

english, 2020

33

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

Britton, Oliver J., Bueno-Orovio, Alfonso, Van Ammel, Karel, Lu, Hua Rong, Towart, Rob, Gallacher, David J., Rodriguez, Blanca

Journal:

Proceedings of the National Academy of Sciences

Year:

2013

Language:

english

File:

PDF, 1.33 MB

english, 2013

34

The Na+/K+ pump is an important modulator of refractoriness and rotor dynamics in human atrial tissue

Sanchez, C., Corrias, A., Bueno-Orovio, A., Davies, M., Swinton, J., Jacobson, I., Laguna, P., Pueyo, E., Rodriguez, B.

Journal:

AJP Heart and Circulatory Physiology

Year:

2012

Language:

english

File:

PDF, 2.77 MB

english, 2012

35

Atrial Fibrillation Dynamics and Ionic Block Effects in Six Heterogeneous Human 3D Virtual Atria with Distinct Repolarization Dynamics

Sánchez, Carlos, Bueno-Orovio, Alfonso, Pueyo, Esther, Rodríguez, Blanca

Journal:

Frontiers in Bioengineering and Biotechnology

Year:

2017

Language:

english

File:

PDF, 5.41 MB

english, 2017

36

Spectral Methods for Partial Differential Equations in Irregular Domains: The Spectral Smoothed Boundary Method

Bueno-Orovio, Alfonso, Pérez-García, Víctor M., Fenton, Flavio H.

Journal:

SIAM Journal on Scientific Computing

Year:

2006

Language:

english

File:

PDF, 428 KB

english, 2006

37

Basis for the Induction of Tissue-Level Phase-2 Reentry as a Repolarization Disorder in the Brugada Syndrome

Bueno-Orovio, Alfonso, Cherry, Elizabeth M., Evans, Steven J., Fenton, Flavio H.

Journal:

BioMed Research International

Year:

2015

Language:

english

File:

PDF, 3.79 MB

english, 2015

38

Human ventricular activation sequence and the simulation of the electrocardiographic QRS complex and its variability in healthy and intraventricular block conditions

Cardone-Noott, Louie, Bueno-Orovio, Alfonso, Mincholé, Ana, Zemzemi, Nejib, Rodriguez, Blanca

Journal:

Year:

2016

Language:

english

File:

PDF, 2.14 MB

english, 2016

39

Improving the clinical understanding of hypertrophic cardiomyopathy by combining patient data, machine learning and computer simulations: A case study

Lyon, A., Mincholé, A., Bueno-Orovio, A., Rodriguez, B.

Journal:

Year:

2019

File:

PDF, 4.34 MB

2019

40

P510Whole atria mechanisms of inducibility and persistence of atrial arrhythmias by depletion of nNOS in human

Muszkiewicz, A., Liu, X., Bueno-Orovio, A., Rodriguez, JF., Casadei, B., Rodriguez, B.

Journal:

Year:

2017

Language:

english

File:

PDF, 239 KB

english, 2017

41

Corrigendum: The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

Britton, Oliver J., Bueno-Orovio, Alfonso, Virág, László, Varró, András, Rodriguez, Blanca

Journal:

Frontiers in Physiology

Year:

2017

Language:

english

File:

PDF, 132 KB

english, 2017

42

Commentary: Atrial Rotor Dynamics Under Complex Fractional Order Diffusion

Bueno-Orovio, Alfonso

Journal:

Frontiers in Physiology

Year:

2018

Language:

english

File:

PDF, 836 KB

english, 2018

43

Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization

Bueno-Orovio, A., Kay, D., Grau, V., Rodriguez, B., Burrage, K.

Journal:

Journal of The Royal Society Interface

Year:

2014

Language:

english

File:

PDF, 1.24 MB

english, 2014

44

[IEEE 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Orlando, FL, USA (2016.8.16-2016.8.20)] 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Effects and underlying mechanisms of refractory period pacing on repolarization dynamics in the human heart

Santos, Diogo, Orini, Michele, Zhou, Xin, Bueno-Orovio, Alfonso, Hanson, Ben, Taggart, Peter, Hayward, Martin, Rodriguez, Blanca, Lambiase, Pier

Year:

2016

Language:

english

File:

PDF, 1.04 MB

english, 2016

45

Inter-Subject Variability in Human Atrial Action Potential in Sinus Rhythm versus Chronic Atrial Fibrillation

Sánchez, Carlos, Bueno-Orovio, Alfonso, Wettwer, Erich, Loose, Simone, Simon, Jana, Ravens, Ursula, Pueyo, Esther, Rodriguez, Blanca, Panfilov, Alexander V.

Journal:

Year:

2014

Language:

english

File:

PDF, 3.74 MB

english, 2014

46

Slow Recovery of Excitability Increases Ventricular Fibrillation Risk as Identified by Emulation

Lawson, Brodie A., Burrage, Kevin, Burrage, Pamela, Drovandi, Christopher C., Bueno-Orovio, Alfonso

Journal:

Frontiers in Physiology

Year:

2018

Language:

english

File:

PDF, 3.69 MB

english, 2018

47

Mapped Chebyshev pseudospectral method for the study of multiple scale phenomena

Adrian Alexandrescu, Alfonso Bueno-Orovio, José R. Salgueiro, Víctor M. Pérez-García

Journal:

Computer Physics Communications

Year:

2009

Language:

english

File:

PDF, 760 KB

english, 2009

48

Anomalous diffusion in cardiac tissue as an index of myocardial microstructure

Bueno-Orovio, Alfonso, Teh, Irvin, Schneider, Jurgen E., Burrage, Kevin, Grau, Vicente

Journal:

IEEE Transactions on Medical Imaging

Year:

2016

Language:

english

File:

PDF, 2.57 MB

english, 2016

49

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy

Passini, Elisa, Mincholé, Ana, Coppini, Raffaele, Cerbai, Elisabetta, Rodriguez, Blanca, Severi, Stefano, Bueno-Orovio, Alfonso

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2016

Language:

english

File:

PDF, 1.77 MB

english, 2016

50

The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

Britton, Oliver J., Bueno-Orovio, Alfonso, Virág, László, Varró, András, Rodriguez, Blanca

Journal:

Frontiers in Physiology

Year:

2017

Language:

english

File:

PDF, 4.07 MB

english, 2017

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